Chapter 1048: Seeding Fungi (only two chapters today, four chapters tomorrow)
"I know what you are thinking, but you can't snatch the credit for this achievement from the other side. And there is no need to do so. At the same time, I also refuse to do so. You are making fun of my academic reputation." Robert spread his hands.

After saying that, he pointed at the author of the paper - ZhenDong.Gao.

"Do you know him? He is the most outstanding computer scholar in the world. He has not published many results, but every result is the first thing that all computer researchers in the world want to learn and follow. You can't block this news. All computer researchers will get it at the first time. Your idea is to invite ridicule. Do you understand? This is not an unknown little scholar!"

After rejecting the Langley Center's request from a moral perspective, Robert also made the people at the Langley Center give up the idea from a technical perspective.

"But anyway, this is good news for you. This encryption method can meet some of your special encryption requirements. You can take a copy of this paper away. Don't worry, you don't need my help. Your computer staff is capable of implementing this algorithm."

The people at the Langley Center took the translation and were about to leave, but Robert stopped them: "Don't you understand what I'm saying? Gentlemen, you can copy it, but you can't take it away. I only have this one copy!"

Looking at the people from the Langley Center who left in disgrace, Robert said to his assistant, "Try to contact the people in the East as quickly as possible. I want to reprint this paper so that more people can see it. It would be best if we can get their authorization."

If he can obtain authorization, Robert still hopes to make this matter more perfect. This is mutual respect among scholars.

Similar things are also happening in the Russian family.

But as comrades in the same camp, they are very happy about this matter.

"Comrade Nan Fang, great work! This is a breakthrough in cryptography."

An old Russian praised his colleague and was very happy. This paper is not only theoretically profound, but also very practical. At least the comrades in Lubyanka will be very happy.

This paper may be worthless from the perspective of mathematics, but it is a major achievement from the perspective of cryptography.

"My dear Mr. Davari, have you noticed a problem? For us, this algorithm requires more powerful computers to implement it on portable or mobile equipment." His colleague looked at the paper and frowned.

This is the flaw of the large number decomposition algorithm. The encryption is relatively fast, but the decryption time is much slower than that of symmetric encryption algorithms such as DES and AES.

With current computer technology, this amount of computation is a bit too much for the Russians, and if they want to make it practical, they lack computers that are small enough.

"I've also discovered that perhaps we still need the help of our comrades in the south. I don't believe they only have C6108 or that kind of simple single-chip microcomputer." The 8-bit computer is indeed a bit too abstract.

"Let's not think about it too much for now. Our job is to implement the algorithm. As for the equipment, let the comrades in charge of trade and communication worry about it."

Similar conversations are also happening within our community.

"Comrade Gao Zhendong really has two completely different algorithms! Genius! In my opinion, he should study mathematics!"

A comrade who studies mathematics praised Gao Zhendong's paper and was quite regretful at the same time. If Gao Zhendong heard this, his first reaction would probably be to run away. He really can't do mathematics. Gao Zhendong knows his own limitations. He can't even understand the questions of most of the unresolved mathematical problems.

"You can't let the comrades from the Defense Work Committee and the 17th Ministry of Machine Building hear this. If it gets out, they might come after you with their weapons. Hahaha." Another comrade laughed.

"Yes, he is good at solving practical problems. With him joining our Department of Mathematics, Physics and Chemistry, he is a new force. Did you notice that he really kept the better algorithms for himself and made public the less powerful algorithms? He can even pick and choose. He is really a genius in application."

The mathematician praised Gao Zhendong's choice of using the algorithms for his own use or making them public. He studied both algorithms.

Compared with large number factorization, the better the encryption performance of the elliptic curve algorithm, the higher the key length ratio. Taking the factorization of 2048-bit large numbers as an example, the elliptic curve key length with the same confidentiality performance is only 210 bits, and the operation time of the latter is only about 1/5~1/4 of the former.

"Well, one for military use and one for civilian use. This is a very good arrangement. Okay, our task now is to explain this algorithm to our comrades. Comrade Zhendong has taken on the task for us."

The two men laughed, but unlike the Russians, they were not worried that we had no computers to use.
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Gao Zhendong returned home from get off work and saw that Lou Xiaoe looked listless again.

He was not in a hurry. This kind of thing would happen occasionally, but Lou Xiao'e was very good at adjusting herself and would get better soon.

"What happened today?" Gao Zhendong handed a glass of water to Lou Xiaoe and asked by the way.

"Nothing, I just felt a little sad seeing another patient pass away. It's okay, it will be fine in a while." Lou Xiao'e smiled and leaned her head on Gao Zhendong's shoulder. "Oh, what's the reason this time?"

"It's the same as the last time. He got off the operating table, but later died of infection. Zhendong, tell me, don't we have penicillin? Why do so many patients still die of infection?" Lou Xiao'e looked at Gao Zhendong.

"Uh... maybe it's because of drug resistance? I remember you were reading a book on antibiotics for some time, so you should know this." Gao Zhendong knew something about it. He watched all kinds of popular science videos, and he had often heard about drug resistance in his previous life, so even if he didn't understand it, he could still know a little bit.

"Yes, it is mentioned in the book. The mechanism is very complicated and the exact cause is uncertain." Lou Xiao'e thought of the knowledge she had learned.

In fact, there are many ways and means for bacteria to develop drug resistance, and there is even less research now, so it is normal that it is not very clear.

"Have you discussed this with your teacher? I remember that there should be antibiotics such as semi-synthetic penicillin and vancomycin now, right?" Gao Zhendong was very interested in talking about this issue because he was concerned about Lou Xiao'e's work.

"It has been discussed before, but we are in thoracic surgery and are not very good at this aspect. The teacher did say that one of the reasons is that β-lactamase breaks down penicillin. With this stuff, no other penicillin will work. The vancomycin you mentioned can't be used at all times, and it's expensive and has high requirements for use. Do you think it's possible to create an antibiotic that is similar in effect and price to penicillin, but is not broken down by this enzyme? Wouldn't that solve part of the drug resistance problem?" Lou Xiao'e didn't study medicine, but she was more or less interested in medicine.

"Why are you interested in medicine? Don't you want to study thoracic surgery anymore?" Gao Zhendong said with a smile.

"You have to learn thoracic surgery. It's normal to be interested in medicine. Besides, you can span multiple fields, so why can't I?" Lou Xiao'e wrinkled her nose, looking very cute.

In her opinion, if Gao Zhendong can span so many fields, then it should be possible for me to span a few, right?

If others knew her thoughts, they would probably feel that she was led astray by Gao Zhendong.

But Gao Zhendong is not an ordinary person. With him around, even if Lou Xiaoe does not cross multiple disciplines, it is always right for her to at least give her some advice.

Gao Zhendong smiled and said, "I think we don't necessarily have to fight against β-lactamase." He had some memories in his head, which were now completely awakened by Lou Xiaoe.

"Not resisting? Won't I still be decomposed?" Lou Xiao'e bit her finger.

"What I mean is that we can inhibit the action of β-lactamase, for example, by counteracting this enzyme first, so that penicillin can play its role normally."

"what do you mean?"

"What I mean is to find something that can be mixed with penicillin to kill both β-lactamase and β-lactamase. This thing doesn't have to be a very good antibiotic, but it must be able to inhibit the action of β-lactamase. Penicillin is still the best at killing bacteria."

Lou Xiao'e thought for a long time and said, "Hey, this method you mentioned seems to work. It may be difficult to find an antibiotic that is both antibacterial and resistant to β-lactamase, but it may be easier to find something that does not affect the effect of penicillin but can preemptively bind to β-lactamase."

This was originally one of the means by which penicillin deals with drug-resistant bacteria. Although it has not been developed yet, related research has already been carried out. After all, β-lactamase was discovered in the 40s.

Thinking of this, Lou Xiao'e became excited: "I will go to the pharmacy teachers tomorrow and talk to them about this idea! Oh, yes, you can help me design a way to find this substance."

Judging from the information in the "Concise Manual for Primary Care Physicians", Lou Xiao'e always felt that Gao Zhendong would definitely be able to find a way, even though his job had nothing to do with these things.

Gao Zhendong tried hard to recall the popular science video he had seen at that time.

"How else can we find it? There's only one way to make antibiotics - grow bacteria."

"Growing bacteria?"

"Yes, if you can get a strain of bacteria that can produce β-lactamase, get a batch of culture medium containing penicillin, dig a few holes in it, put the extracts of various microorganisms in, and culture the strain of bacteria that can produce β-lactamase in the culture medium at the same time. If the microbial extract is effective, then bacteria will not grow around the small holes. Otherwise, this strain of bacteria will grow all over the culture medium."

This is John Bull's way, and in this regard, John Bull is still trustworthy.

(End of this chapter)